Cardiovascular & Circulation
What the literature actually shows about supporting heart, vessels, and lipid handling — sorted by evidence tier, not by what’s loudest in marketing. Useful whether you track lipids on a dashboard or just want to age well.
Start from a number.
Each biomarker clusters the supplements and articles with measurable impact on that marker. Drill in for ranges, mechanisms, and what the evidence actually moves.
Apolipoprotein B — count of atherogenic particles. The single most informative lipid number; targets vary with risk profile.
High-sensitivity C-reactive protein. > 3 mg/L flags systemic inflammation that accelerates plaque progression.
Amino acid elevated in B-vitamin deficiency. > 11 µmol/L associated with vascular damage; responsive to B-complex sufficiency.
Lipid Handling
Apo-B, LDL particle count, triglyceride-to-HDL ratio, and the supplements with replicated effects on each. Where the diet-vs-supplement debate has the cleanest evidence base.
Your Heart Health Advantage: A Comprehensive Guide for Men in Their 20s and 30s
Cardiovascular Health After Menopause: The Risk Women Were Never Warned About
Cardiovascular Health After 65: Protecting the Engine When the Stakes Are Highest
Vascular Function
Endothelial reactivity, nitric-oxide pathways, arterial stiffness. The downstream of metabolic and inflammatory state — and where the reversibility data is most encouraging.
The Heart Disease Blind Spot: A Comprehensive Guide to Cardiovascular Health for Women 18–39
Cardiovascular Health After 40: Why Midlife Women Need a New Playbook
Cardiovascular Mastery for Men 40–65: Precision Strategies to Outpace Heart Disease
Blood Pressure
What actually moves systolic and diastolic numbers in a clinically meaningful way. Most over-the-counter claims here are smaller than a mediocre walking habit.
Why Your LDL Target Should Be Personal, Not Universal
Calcium's Sex-Specific IGF-1 Effect: Why the Same Supplement Raises One Child's Growth Hormone and Lowers Another's
Your Vitamin A Supplement Could Be Silently Elevating TSH and Triglycerides — Or Doing Nothing At All
Cardiovascular Inflammation
hs-CRP, IL-6, and the chronic low-grade inflammation that drives plaque progression. Heavy overlap with neuroinflammation and metabolic dysregulation.
Niacin Raises HDL 21% But Fails to Cut Heart Attacks: The Biomarker Trap That Fooled Cardiologists for Decades
GABA Supplements Can't Cross the Blood-Brain Barrier — So Why Do Some People Swear By Them?
L-Citrulline Cuts Blood Pressure as Effectively as Exercise — But Only If Your Vascular System Responds
Rhythm & Electrolyte Support
Magnesium, potassium, taurine, and the electrolyte balance that keeps cardiac rhythm steady. Often overlooked, occasionally critical.
The metformin interaction that makes berberine more complicated for people already on diabetes medication
The omega-3 index as a status marker: what the proven blood response tells you that dose labels cannot
Versioned Article
Ranked by evidence tier.
Every supplement with published evidence for Cardiovascular & Circulation. Tiering reflects the strength of the primary literature, not market popularity.
- Omega 36 articles
- Homocysteine1 article
- Ldl Cholesterol1 article
- Calcium1 article
- Gaba1 article
- L Citrulline1 article
- Ldl Cholesterol1 article
- Magnesium1 article
- Niacin1 article
- Omega 3 Fatty Acids1 article
- Vitamin A1 article
Questions Aviado Research hears on this pillar.
Why does Aviado lead with Apo-B instead of LDL-C?
Editorial draft pending — Apo-B counts atherogenic particles directly; LDL-C estimates cholesterol per particle and can underestimate risk in metabolic dysfunction. Brief, citation-light, no testing-imperative.
How do evidence tiers apply to this pillar specifically?
Editorial draft pending — Restate the 4-tier rubric with cardiovascular examples. Note that hard outcome trials (MACE, mortality) are weighted more heavily than surrogate-endpoint trials when the literature offers both.
Where do supplements fit alongside statins, PCSK9s, or BP meds?
Editorial draft pending — Adjunct framing only. Aviado does not position supplements as substitutes for prescribed therapy. Cross-link to /methodology/ for how interaction risks are flagged.
How often is this pillar refreshed?
Editorial draft pending — Quarterly cadence; out-of-band re-reviews triggered by new meta-analyses, regulatory action (e.g. red-yeast-rice rulings), or safety signals.
Heart and vessels, tiered honestly.
Browse every article in this pillar filtered by evidence tier, supplement, biomarker, or sub-theme.
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